代謝システム研究チーム

研究室一覧へ

実績

2024-present ｜ 2026 ｜ 2025 ｜ 2024 ｜ 2005-2023 ｜

2026

原著論文

Yoshioka, H., Debeljak, P., Prado, S., Fuji, Y., Ichihashi, Y. and Iwata, H. (2026) Interpretable multi-omics machine learning reveals drought-driven shifts in plant–microbe interactions, Environ Microbiome,21(1):57, DOI: 10.1186/s40793-026-00883-x.

Shoji, T., Fukushima, A., Morinaka, H., Takagi, H., Nakashima, Y., Mori, T., Kawamura, A., Shi, D., Torii, K., Iwase, A., Takeda-Kamiya, N., Toyooka, K., Morita, H., Hirai, M.Y., Sugimoto, K., Saito, K. and Hirai, T. (2026) Multi-omics dissection of steviol glycoside synthesis reveals haplotype-linked specialization of UGT76G genes in Stevia rebaudiana. New Phytol, DOI: 10.1111/nph.71191.

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2025

原著論文

Dang, T., Fuji, Y., Kumaishi, K., Usui, E., Kobori, S., Sato, T., Narukawa, M., Toda, Y., Sakurai, K., Yamasaki, Y., Tsujimoto, H., Hirai, M.Y., Ichihashi, Y. and Iwata, H. (2025) I-SVVS: Integrative stochastic variational variable selection to explore joint patterns of multi-omics microbiome data, Brief Bioinform, 26(3), bbaf132, DOI: 10.1093/bib/bbaf132.

Akiyama, R., Kawano, Y., Shimizu, K., Makino, S., Akanuma, K., Nagatomo, H., Hirai, M.Y., Sugimoto, Y., Kushida, A., Tanino, K. and Mizutani, M.(2025) Solanoeclepin C, a root-secreted molecule converted by rhizosphere microbes to hatching factors for potato cyst nematodes. New Phytol 247: 1370-1381. DOI: 10.1111/nph.70252.

Tabeta, H., Uzaki, M. and Hirai, M.Y.(2025) Spatial metabolomics as a new avenue in plant developmental biology: insights into serine biosynthesis during spermatogenesis in Marchantia polymorpha. Plant Signal Behav 20:2571669. DOI: 10.1080/15592324.2025.2571669.

Zait, Y., Zhu, M., Ando, E., Zhou, Y., Yaaran, A., Yon, S., Okamoto, M., Hayashi, Y., Hirai, M.Y., Jegla, T., Kinoshita, T., Chen, S. and Assmann, S.M.(2025) Apoplastic metabolomics reveals sugars as mesophyll messengers regulating guard cell ion transport under red light. Nat. Plants. 11:1847–1862. DOI: 10.1038/s41477-025-02078-7.

Kawade, K., Nozaki, M., Horiguchi, G., Mori, T., Yamaguchi, K., Okamoto, M., Tabeta, H., Shigenobu, S., Hirai, M.Y. and Tsukaya, H.(2025) Loss-of-functional mutation in ANGUSTIFOLIA3 causes leucine hypersensitivity and hypoxia response during Arabidopsis thaliana seedling growth.Metabolomics. 21:46. DOI:10.1007/s11306-025-02249-9.

Yoshioka, H., Mary-Huard, T., Aubert, J., Toda, Y., Ohmori, Y., Yamasaki, Y., Tsujimoto, H., Takahashi, H., Nakazono, M., Takanashi, H., Fujiwara, T., Tsuda, M., Kaga, A., Inaba, J., Fuji, Y., Hirai, M.Y., Nose, Y., Kumaishi, K., Usui, E., Kobori, S., Sato, T., Narukawa, M., Ichihashi, Y. and Iwata, H. (2025) Integration of Proxy Intermediate Omics traits into a Nonlinear Two-Step model for accurate phenotypic prediction.bioRxiv 18:2. DOI:10.1101/2025.03.14.643213.

Osuga, Y., Harada, K., Yamauchi, T., Kitaguchi, T., Hirai, M.Y., Matsumoto, M. and Tsuboi, T. (2025) Taurine promotes glucagon-like peptide-1 secretion in enteroendocrine L cells.FEBS Lett. DOI:10.1002/1873-3468.70014.

Kim, J.-S., Sato, M., Kojima, M., Asrori, M.I., Uehara-Yamaguchi, Y., Takebayashi, Y., Do, T.N., Do, T.Y., Nguyen Thi, K.O., Sakakibara, H., Mochida, K., Ogita, S. and Hirai, M.Y.(2025) Multiomics-based assessment of the impact of airflow on diverse plant callus cultures.Sci Data. 12:197. DOI:10.1038/s41597-025-04518-7.

Zhao, X., Su, H., Kong, X., Hirai, M.Y., Yan, X., Li, R. and Li, J. (2025) Overexpression of BoSULTR1;1/BoSULTR1;2 promotes glucosinolate accumulation and enhances stress tolerance in broccoli. Sci. Hortic. 339. DOI:10.1016/j.scienta.2024.113883.

Okamoto, T., Hotta, Y., Shinjo, R., Masuda, Y., Nishihara, A., Sasaki, R., Hirai, M.Y., Nishiwaki, R., Miyado, S., Sugiura, D. and Kondo, M. (2025) Unelongated Stems are an Active Nitrogen-Fixing Site in Rice Stems Supported by Both Sugar and Methane Under Low Nitrogen Conditions. Rice 18:2. DOI:10.1186/s12284-025-00757-9.

Harada, K., Wada, E., Osuga, Y., Shimizu, K., Uenoyama, R., Hirai, M.Y., Maekawa, F., Miyazaki, M., Hayashi, Y.K., Nakamura, K. and Tsuboi, T. (2025) Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice.Mol Metab. 91:102072. DOI:10.1016/j.molmet.2024.102072.

プレプリント

Yoshioka, H., Mary-Huard, T., Aubert, J., Toda, Y., Ohmori, Y., Yamasaki, Y., Tsujimoto, H., Takahashi, H., Nakazono, M., Takanashi, H., Fujiwara, T., Tsuda, M., Kaga, A., Inaba, J., Fuji, Y., Hirai, M.Y., Nose, Y., Kumaishi, K., Usui, E., Kobori, S., Sato, T., Narukawa, M., Ichihashi, Y. and Iwata, H. (2025) Integration of Proxy Intermediate Omics traits into a Nonlinear Two-Step model for accurate phenotypic prediction.bioRxiv. 18:2. DOI:10.1101/2025.03.14.643213.

その他の発行物

バイオサイエンスとインダストリー83巻1号
「根の形態を制御可能な機能性アミノ酸：2-アミノピメリン酸」
多部田弘光、平井優美

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2024

巻頭言（エディトリアル）

Mitsuda, N., Seki, H., Shoji, T., and Hirai, M.Y. (2024) Preface to the special issue “Synthetic Biology and Bioproduction in Plants”, Plant Biotechnology 41: 169-171.

Li-Beisson, Y., Hirai, M.Y., Nakamura, Y. (2024) Plant metabolomics. Journal of Experimental Botany 75: 1651–1653.

原著論文

Dang, T., Fuji, Y., Kumaishi, K., Usui, E., Kobori, S., Sato, T., Toda, Y., Sakurai, K., Yamasaki, Y., Tsujimoto, H., Hirai, M.Y., Ichihashi, Y. and Iwata, H. (2024) I-SVVS: Integrative stochastic variational variable selection to explore joint patterns of multi-omics microbiome data bioRxiv. DOI: 10.1101/2023.08.18.553796

Uchida, K., Fuji, Y., Tabeta, H., Akashi, T. and Hirai, M.Y. (2024) Omics-based Identification of the Broader Effects of 2-hydroxyisoflavanone Synthase Gene Editing on a Gene Regulatory Network Beyond Isoflavonoid Loss in Soybean Hairy Roots Plant Cell Physiol.. DOI: 10.1093/pcp/pcae151

Okada, M., Barras, C., Toda, Y., Hamazaki, K., Ohmori, Y., Yamasaki, Y., Takahashi, H., Takanashi, H., Tsuda, M. and Hirai, M.Y. , et al.(2024) High-Throughput Phenotyping of Soybean Biomass: Conventional Trait Estimation and Novel Latent Feature Extraction Using UAV Remote Sensing and Deep Learning Models, Plant Phenomics. 2024;6:0244, DOI: 10.34133/plantphenomics.0244.

Fuji, Y., Matsufuji, H. and Hirai, M.Y. (2024) Distribution, biosynthesis, and synthetic biology of phenylethanoid glycosides in the order Lamiales, Plant Biotechnology. 41: 231-241, DOI: 10.5511/plantbiotechnology.24.0720a.

Kim, J.-S., Sato, M., Kojima, M., Asrori,M.I., Uehara-Yamaguchi, Y., Takebayashi, Y., Do, T.N., Do, T.Y., Nguyen, K.-O.T., Sakakibara, H., Mochida, K., Ogita, S. and Hirai, M.Y. (2024) Multi-omics signatures of diverse plant callus cultures, Plant Biotechnology. 41: 309-314, DOI: 10.5511/plantbiotechnology.24.0719a.

Ishii, K., Kazama, Y., Hirano, T., Fawcett, J.A., Sato, M., Hirai, M.Y., Sakai, F., Shirakawa, Y., Ohbu, S. and Abe, T.(2024) Genomic view of heavy-ion-induced deletions associated with distribution of essential genes in Arabidopsis thaliana. Front Plant Sci.. 15:1352564. DOI: 10.3389/fpls.2024.1352564.

Tabeta, H. and Hirai, M.Y.(2024) L-2-Aminopimelic acid acts as an auxin mimic to induce lateral root formation across diverse plant species. FEBS Letters. DOI:10.1002/1873-3468.14908

Nguyen, P.N., Do, T.Y., Do, T.N., Gontier, E., Nguyen, H.T.L., Thi, V.A.L., Mai, N.T.P., Sato, M., Hirai, M.Y. and Nguyen, K.-O.T.(2024) Widely targeted metabolomics reveals the species-specific, matureness-specific and post-harvest-specific discriminations in the chemical profiles of Vietnamese endemic golden camellias. Int J Food Sci Technol. DOI:10.1111/ijfs.17071

Uzaki, M., Mori, T., Sato, M., Wakazaki, M., Takeda-Kamiya, N., Yamamoto, K., Murakami, A., Guerrero, D.A.S., Shichijo, C., Ohnishi, M., Ishizaki, K., Fukaki, H., O'Connor, S.E., Toyooka, K., Mimura, T. and Hirai, M.Y.(2024) Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus. New Phytol. DOI:10.1111/nph.19662

Miyaji, S., Ito, T., Kitaiwa, T., Nishizono, K., Agake, S.-I., Harata, H., Aoyama, H., Umahashi, M., Sato, M., Inaba, J., Fushinobu, S., Yokoyama, T., Murayama-Nakashita, A., Hirai, M.Y. and Ohkama-Ohtsu, N.(2024) N²-Acetylornithine deacetylase functions as a Cys-Gly dipeptidase in the cytosolic glutathione degradation pathway in Arabidopsis thaliana Plant J.. DOI:10.1111/tpj.16700.

Wang, M., Tabeta, H., Ohtaka, K., Kuwahara, A., Nishihama, R., Ishikawa, T., Toyooka, K., Sato, M., Wakazaki, M., Akashi, H., Tsugawa, H., Shoji, T., Okazaki, Y., Yoshida, K., Sato, R., Ferjani, A., Kohchi, T., Hirai, M.Y. (2024) The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha. Commun Biol. DOI:10.1038/s42003-023-05746-6.

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